. 2013 Jan 23;6:1–14. doi: 10.2147/IDR.S26134

Table 2.

Randomized controlled trials evaluating topical antibiotics in CRS

Author	Year	Outcome measures	Treatment groups	Treatment protocol	Result
Sykes et al⁶⁸	1986	Symptoms, bacterial culture, sinus radiograph, saccharin clearance, allergy testing	Dexamethasone/tramazoline/neomycin versus dexamethasone/ tramazoline versus placebo	Nasal spray QID × 4 weeks	Improvements in both treatment groups over placebo; no difference with addition of topical antibiotic
Desrosiers et al⁶⁹	2001	Symptoms, QoL, endoscopy	Tobramcyin in saline versus saline	Large-particle nebulizer TID × 4 weeks	Improvements in both groups; no benefit of tobramycin over saline
Videler et al⁷⁰	2008	Symptoms, QoL, endoscopy	Bacitracin/colimycin versus placebo	RhinoFlow nebulizer BID + oral levofloxacin	Improvements in both groups, with no benefit over placebo
Jervis-Bardy et al⁷¹	2012	Bacterial culture, symptoms, endoscopy post-ESS	Mupirocin versus saline in Staphylococcus aureus-positive patients	240 mL irrigation BID × 1 month	Staphylococcus aureus culture negativity in 88.9% of mupirocin versus 0% of saline group; improved early endoscopic score in mupirocin group over saline; no difference in symptoms between groups

Abbreviations: CRS, chronic rhinosinusitis; QID, four times daily; QoL, quality of life; TID, three times daily; BID, twice daily; ESS, endoscopic sinus surgery.