Table 4.
Effect of rivastigmine solution (RS) and rivastigmine liposome formulation (RL) on plasma CRP, Hcy, ADMA, and brain AChE and Na+/K+-ATPase activities in AlCl3-treated rats
| Groups | Control | Al | Al + RS | Al + RL |
|---|---|---|---|---|
| Parameters | ||||
| CRP (mg/L) | 4.0 ± 0.42 | 8.5 ± 0.89a | 5.9 ± 0.38a,b | 5.7 ± 0.46a,b |
| Hcy (μmol/L) | 3.8 ± 0.47 | 9.2 ± 0.64a | 6.3 ± 0.64a,b | 5.5 ± 0.6a,b |
| ADMA (μmol/L) | 0.86 ± 0.11 | 2.47 ± 0.21a | 1.6 ± 0.19a,b | 1.73 ± 0.18a,b |
| AChE (U/mg protein) | 419.6 ± 33.2 | 674.3 ± 38.2a | 545 ± 26.6a,b | 494.5 ± 28.7b |
| Na+/K+ATPase (μmol/Pi/hour/mg protein) | 6.41 ± 0.6 | 2.67 ± 0.29a | 4.55 ± 0.37a,b | 5.8 ± 0.5b |
Notes:aSignificantly different from the control group;
bsignificantly different from AlCl3-treated group at P < 0.05. Values are expressed as means ± standard error of eight rats.
Abbreviations: CRP, C-reactive protein; Hcy, homocysteine; ADMA, asymmetric dimethylarginine; AChE, acetylcholinesterase; ATPase, adenosine triphosphatase; AlCl3, aluminium chloride.