Table 7.
p53 alterations
| IHC status of p53(a) | Mutation status of TP53(b) | Type of TP53 mutation(c) | All (%) | ||
|---|---|---|---|---|---|
| |
- |
+ |
ms |
tm |
|
| - |
96 |
11 |
1 |
10 |
107 (80) |
|
+ |
7 |
20 |
19 |
1 |
27 (20) |
| All (%) | 103 (77) | 31 (23) | 20 (15) | 11 (8) | 134 (100) |
(a) +: Immunohistochemical detection of p53 accumulation in at least 10% of tumor cells, -: no p53 signal; (b) +: detection of a mutation of TP53 (listed in Additional file 2), -: wild type TP53; (c) ms: missense mutation, tm: truncated mutation (frameshift or nonsense).