SRC proximal and core promoter elements can confer TSA-mediated repression on the WAF1 promoter. Wild-type SRC1A and WAF1 promoter constructs depicted in panel A, as well as various promoter chimeras, were assessed for their response to 1 μM TSA following transfection in HT29 and SW480 cells (B). Wild-type SRC1α and WAF1 promoter constructs depicted in panel A, as well as various promoter chimeras, were assessed for their response to 1 μM TSA following transfection in HT29 and SW480 cells (C). Act, activity.