Table 2.
Association of polymorphisms in ADRB2 gene with spirometry of Cystic Fibrosis patients1
| Variable | Arg16Gly | Gln27Glu | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| |
Arg/Arg |
Arg/Gly |
Gly/Gly |
F |
p |
Gln/Gln |
Gln/Glu |
Glu/Glu |
F |
p |
| FVC (%) |
23 (82.04 ± 4.48) |
54(79.30 ± 3.21) |
44(75.05 ± 3.43) |
3.25 |
0.08 |
63(77.9 ± 2.92) |
48(79 ± 3.37) |
10(77.1 ± 6.48) |
0.02 |
0.90 |
| FEV1 (%) |
23(72 ± 5.57) |
53(72.57 ± 3.47) |
44(66.64 ± 4.10) |
6.80 |
0.01 |
62(70.34 ± 3.49) |
48(70.75 ± 3.63) |
10(67.70 ± 8) |
0.45 |
0.50 |
| FEV1/FVC |
23(82 ± 4.27) |
52(84.79 ± 1.82) |
44(83.33 ± 2.44) |
1.12 |
0.29 |
62(85.32 ± 1.9) |
47(82.21 ± 2.48) |
10(82.20 ± 4.96) |
0.17 |
0.68 |
| FEF25-75% | 23(58.17 ± 7.22) | 53(59.91 ± 4.48) | 44(56.98 ± 5.75) | 5.82 | 0.02 | 62(61.34 ± 4.64) | 48(55.88 ± 4.84) | 10(53.50 ± 9.99) | 1.23 | 0.27 |
% - Percentage; FVC - forced vital capacity; FEV - forced expiratory volume; FEF25-75% - forced expiratory flow between 27-75% of the FVC. 1. Continuous variables expressed as number of patients (mean ± SD (range). Statistical analysis conducted by analysis of variance (ANOVA) through (in bold) statistically significant values with less than 0.05.