TABLE 2.
Antibody production in APS−/− mice
| Genotype (n)a | Mean serum Ig level (μg/ml) ± SEM forb:
|
|||||
|---|---|---|---|---|---|---|
| IgM | IgG1 | IgG2a | IgG2b | IgG3 | IgA | |
| +/+ (9) | 120 ± 10 | 180 ± 67 | 90 ± 30 | 260 ± 42 | 49 ± 4.3 | 85 ± 9.5 |
| −/− (12) | 140 ± 13 | 150 ± 46 | 77 ± 17 | 200 ± 36 | 79 ± 6.9c | 84 ± 7.1 |
a
n, number of mice.
b
Concentrations of immunoglobulin subclasses in serum as determined by isotype-specific ELISA. Statistical analysis was carried out by using Student's t test.
c
Significantly different from the value for +/+ mice at a P value of <0.005.