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. 2013 Jan 29;11(1):e1001473. doi: 10.1371/journal.pbio.1001473

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© 2013 Swart et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Relative nanochromosome copy number distribution (number of telomere-less reads/bp of nonsubtelomeric nanochromosome; see Materials and Methods) for homozygous matchless, heterozygous matchless, and heterozygous matching nanochromosomes. The mean copy number of the combined homozygous matchless and heterozygous matchless nanochromosomes is indicated by a dashed line at 0.94, with dotted lines corresponding to an interval of ∼1.3σ (∼0.12 to 1.76) either side of the mean, which includes ∼90% of all nanochromosomes. (B) Relative nanochromosome copy number of nonalternatively fragmented (with a single, directional fragmentation site per nanochromosome) versus alternatively fragmented nanochromosomes measured by the number of telomeric reads per nanochromosome. (C) Relative nanochromosome copy number of nonalternatively fragmented chromosomes versus nonalternatively fragmented chromosomes encoding ribosomal proteins and tRNAs.