Figure 7. INaP evoked by a 10 s step stimulus to −50 mV.
Current traces are shown under control conditions (gray line) and in the presence of 100 µM PHT (black line) in a representative layer V neuron (A); note that the amplitude of the current in the first few hundred milliseconds of the trace is unaffected by PHT (inset in A). The average of the currents obtained in five layer V neurons and normalized to the maximum (B) shows that the decay time constant describing the current inactivation is accelerated and enhanced in the presence of PHT (middle panel). The decay was fit with a mono-exponential relationship (tick line); Note that in these experiments the effect of PHT is particularly small because at −50 mV INaP inactivation is minimal. See text for details.