Figure 8. Effect of PHT on recovery from I_NaP inactivation.

A, representative traces in control (above) and with 100 μM PHT (below) recorded after a 20 s-long inactivating prepulse to −10 mV and a recovery period at −80 mV of 1 ms, 1000 ms, 4000 ms, 10000 ms and 40000 ms (see stimulus in B). B, plot showing average recovery in control (black triangles) and with 100 μM PHT (hollow triangles). The lines are single exponentials obtained averaging the parameters of the fits of the single cells (see text for details).