Table 1. Parameters of activation, voltage-dependence and time-dependent inactivation under control conditions and in the presence of PHT.
| Control | PHT 100μM | ||
| Activation (n = 21; LV and LII-III pooled) | |||
| V½ (mV) | −43.6±0.9 | −44.6±1.2 | |
| K (mV) | 3.1±0.1 | 3.2±0.2 | |
| Steady state inactivation (n = 6, pooled)) | |||
| V½ (mV) | −35.3±1.1 | −44.3±1.3** | |
| K (mV) | 9.1±1.2 | 7.3±0.5 | |
| Time dependent inactivation | |||
| Layer V at -20mV(n = 10) | τ1 (ms) | 680±120 | 330±50** |
| Aτ1 (%) | 28±3 | 29±4 | |
| τ2 (ms) | 9000±1500 | 6800±800* | |
| Aτ2 (%) | 44±4 | 45±4 | |
| Baseline (%) | 27±3 | 25±4 | |
| Layer V at +40mV (n = 9) | τ1 (ms) | 167±24 | 115±20* |
| Aτ1 (%) | 30±4 | 39±5 | |
| τ2 (ms) | 4873±375 | 1850±321* | |
| Aτ2 (%) | 54±6 | 45±5 | |
| Baseline (%) | 16±3 | 16±4 | |
| Layer II-III at -20mV (n = 8) | τ1 (ms) | 350±70 | 125±40* |
| Aτ1 (%) | 28±2 | 31±3 | |
| τ2 (ms) | 8800±500 | 4800±600* | |
| Aτ2 (%) | 45±3 | 43±4 | |
| Baseline (%) | 24±2 | 23±3 |
*
= p<0.05;** = p<0.01 (paired t-test). These values have not been corrected for the junction potential error (see Methods).