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Diagrammatic representation of sister chromatid separation. Sister chromatids are held together by cohesin complexes (short black bars) during metaphase. APCCdc20 ubiquitination of securin (red) leads to liberation of separase (blue). Separase cleaves Scc1, one of the subunits of the cohesin complex, and sister chromatids are pulled apart by spindle microtubules (long black bars).
