TABLE 1.
Orthologues of APC subunits in C. elegans
| Known APC subunitb | APC orthologue in C. elegans (reference[s]) | Function(s) in C. elegansa |
|---|---|---|
| Cdc16 (TPR motif) | emb-27/pod-6 (17, 56) | Progression through meiosis, a-p polarity |
| Cdc23 (TPR motif) | mat-3/pod-4 (9, 20, 56) | Progression through meiosis, mitosis, a-p polarity, affects development (e.g., male tail) |
| Cdc27 (TPR motif) | mat-1/pod-5 (20, 56, 61) | Progression through meiosis, a-p polarity, affects development (e.g., vulva and male tail) |
| Apc1 (Rpn1/2 homology) | mat-2/pod-3 (9, 20, 49) | Progression through meiosis, a-p polarity, affects development of vulva and male tail |
| Apc2 (Cullin homology) | K06H7.6 (9) | Progression through meiosis |
| Apc4 (WD40 repeats) | emb-30 (17) | Progression through meiosis, mitosis, affects development (e.g., vulva and male tail) |
| Apc5 (TPR motif) | M163.4 (9) | Mitosis |
| Apc-10 | F15H10.3 (9) | Mitosis |
| Apc11 | F35G12.9 (9) | Progression through meiosis |
| Cdc26 | ||
| Doc-1 | ||
| Ama-1 | ||
| Cdc20 (WD40 repeats) | fzy-1 (36, 56) | Progression through meiosis, mitosis, a-p polarity |
| Cdh1 (WD40 repeats) | fzr-1 (14) | Mitosis, cyclin destruction, affects germ line proliferation |
a
a-p, anterior-posterior.
b
TPR, tetratricopeptide repeat.