Table 2.
Adjusted odds ratio (OR) and 95% confidence intervals (CI) for postmenopausal breast cancer by plasma MMP levels
| Geometric Mean (pg/ml) (Mean±SD) |
Across 2 SD of the log-transformed MMP values b |
Quartiles (Q) d | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||||||||||
| Cases (n=713) |
Controls (n=713) |
P-value a | OR | (95% CI) c | OR | OR | (95% CI) c | OR | (95% CI) c | OR | (95% CI) c | Ptrendc,e | |
| MMP-1 | 81.7±0.81 | 78.7±0.82 | 0.37 | 1.07 | (0.93 – 1.23) | 1.00 | 0.80 | (0.59 – 1.09) | 0.93 | (0.70 – 1.25) | 1.04 | (0.77 – 1.41) | 0.32 |
| MMP-2 | 20.4±1.79 | 20.5±0.21 | 0.58 | 0.82 | (0.44 – 1.53) | 1.00 | 1.06 | (0.78 – 1.42) | 0.87 | (0.63 – 1.20) | 0.87 | (0.63 – 1.21) | 0.53 |
| MMP-3 | 1.22±0.46 | 1.22±0.49 | 0.86 | 0.93 | (0.62 – 1.39) | 1.00 | 1.01 | (0.74 – 1.37) | 0.97 | (0.71 – 1.32) | 1.02 | (0.75 – 1.38) | 0.72 |
| MMP-7 | 167.0±0.63 | 163.4±0.68 | 0.50 | 1.04 | (0.87 – 1.25) | 1.00 | 1.07 | (0.79 – 1.47) | 1.07 | (0.78 – 1.47) | 1.00 | (0.72 – 1.39) | 0.64 |
Abbreviation: MMP, matrix metalloproteinase; SD, standard deviation.
a
P-value for the difference between cases and controls based on paired t-test.
b
Two SD of the log-transformed MMPs: 1.60 for MMP-1; 0.37 for MMP-2; 0.55 for MMP-3; 1.29 for MMP-7.
c
Modeled through conditional logistic regression after adjustment for body mass index, number of live births, and family history of breast cancer.
d
Medians for the quartiles: 3.53, 4.14, .4.59, 5.27 for MMP-1; 2.88, 3.02, 3.12, 3.25 for MMP-2; 0.56, 0.72, 0.86, 1.09 for MMP-3; 4.51, 4.92, 5.25, 5.71 for MMP-7.
e
P value for the continuous log-transformed MMP level.