Fig. 1.
Basal changes in cAMP signaling in aged animals (19 months) as compared to young adult animals (3 months). (A) cAMP levels in the right parietal cortex, hippocampus, and thalamus from aged animals (n=8 at 15 min and n=7 at 60 min after sham surgery) were analyzed relative to cAMP levels from young adult animals (n=8 at 15 min and n=8 at 60 min after sham surgery). (B) Basal levels of phosphorylated CREB and total CREB in aged animals were analyzed relative to young adult animals in the right parietal cortex (n=12/group) and hippocampus (n=8/group). *P<0.05 for aged versus young adult.