Table 1.

Procoagulant activity of TF mutants lacking Cys186-Cys209 disulfide bond in different studies

TF	FXa generated, nM/min		Ref
	FVIIa, 10 nM	FVIIa, 100–250 nM
TF wt	45.0 (100%)1	30.0 (100%)	Rehemtulla et al.[71]
TFC186/S/C209S	7.5 (17%)	12.0 (40%)
TF wt	1.3 (100%)2		Ahamed et al.[66]
TFC209A	0.1 (8%)
TF wt	9.8 (100%)3	9.6 (100%)	Kothari et al.[32]
TFC186S/C209S	3.9 (40%)	8.1 (84%)
TF wt	0.45 (100%)4		Ruf and Versteeg [86]
TFC209A	0.06 (13%)
TF wt	3.2 (100%)5		Kothari et al.[43]
TFC209S	0.9 (13%)
TFwt	5.0 (100%)6	6.0 (100%)	Van den Hengel et al.[72]
TFC209A	0.2 (4%)	1.0 (17%)
TFC209S	1.3 (26%)	3.0 (50%)
TFC186S/C209S	0.5 (10%)	1.0 (17%)

¹FX, 2 μM, CHO cells;

²concentrations of FX and FVIIa were not clearly specified, HUVEC;

³FX, 1 μM, HUVEC;

⁴FX, 100 nM, HUVEC;

⁵FX, 175 nM, HUVEC;

⁶FX, 100 nM, BHK cells.