Fig. 6.

Reversion by F17141 and clozapine of social interaction deficits induced by chronic NMDA-R blockade by MK-801 in mice. A continuous 7-day treatment with MK-801 (0.02 mg kg^-1 h^-1, s.c.) induced a robust reduction of social interaction time (a, P = 0.0014, by LSD post hoc test) and an increase in escape behavior (b, P = 9.7 × 10^-8, by LSD post hoc test) displayed by the resident mice compared to saline controls. (a) F17141 (0.16–10 mg kg^-1 i.p.) acutely administered 30 min before the test dose dependently, and completely at the highest doses, reversed the social interaction time deficits (a, ANOVA F _5,57 = 4.0, P = 0.0033), and the escape behavior time increase (b, ANOVA F _5,57 = 9.3, P = 1.6 × 10^-6). Clozapine (Cloz), used as an internal control, administered acutely at the challenge dose of 1 mg kg^-1 i.p. 30 min before the test, completely reversed social investigation deficits (a, ANOVA F _2,38 = 8.85, P = 6.9 × 10^-4) and the exacerbated escape behavior induced by MK-801 (b, ANOVA F _2,38 = 15.9, P = 9.3 × 10^-9). Results are mean ± SEM of N = 8–15 animals. *P < 0.05, **P < 0.01, and ***P < 0.005 vs. Sal + Sal and ^# P < 0.05, ^## P < 0.01, and ^### P < 0.005 vs. MK + Sal, by ANOVA followed by Fischer’s LSD post hoc test