Table 1.
Characteristics of Study Participants at Time of Skin Fluorescence Assessment
| Baseline characteristic | Total population | MHRI | Pittsburgh | P value (between sites) |
|---|---|---|---|---|
| Participants (n)a | 172 | 60 | 112 | NA |
| Age (years) | 48.9 (8.62) | 49.4 (8.99) | 48.7 (7.38) | 0.62 |
| Female [n (%)] | 93 (54.1) | 30 (50.0) | 63 (56.3) | 0.43 |
| Black or African-American [n (%)] | 6 (3.5) | 2 (3.3) | 4 (3.6) | 1.00 |
| History of smoking [n (%)] | 43 (28.5) (n=151) | 10 (23.3) (n=43) | 36 (33.3) (n=108) | 0.22 |
| Gross proteinuria [n (%)] | 35 (20.7) (n=169) | 5 (8.6) (n=58) | 30 (27.0) (n=111) | 0.01 |
| Duration of disease (years) | 36.1 (10.54) | 28.6 (11.88) | 40.1 (7.08) | <0.0001 |
| Average length of follow-up (years) | 16.6 (5.45; 3.74–23.68) | 10.27 (4.84; 3.74–23.68) | 20 (0; 20–20) | <0.0001 |
| Mean HbA1c | 8.4 (1.10) | 7.83 (0.95) | 8.77 (1.04) | <0.0001 |
| Most recent HbA1c | 7.7 (1.38) | 7.8 (1.05) | 7.6 (1.53) | 0.34 |
| Recent serum creatinine | 1.1 (0.70) | 1.0 (0.41) | 1.2 (0.80) | 0.07 |
| eGFR | 80.3 (27.29) (n=171) | 83.0 (23.97) (n=59) | 78.2 (28.88) (n=112) | 0.34 |
| Log (SIF×1,000) | 2.1 (0.30) | 1.9 (0.29) | 2.2 (0.26) | <0.0001 |
Data are mean (SD) or mean (SD; minimum–maximum) values unless indicated otherwise, presented by overall population and by site of study.
a
For participants with a hemoglobin A1c (HbA1c) value within 5 years.
eGFR, estimated glomerular filtration rate; MHRI, MedStar Health Research Institute; NA, not applicable; SIF, skin intrinsic fluorescence.