Table 4.

Sex differences in PPI effects for the left PAG in 26 male and 34 female subjects.^a

Region	Peak			Cluster		Peak T value
	x	y	z	PFWE	Size
Left PAG PPI effects, men > women
Left amygdala	−22	−2	−12	0.000	58	6.4
Right cuneus	22	−60	38	0.001	36	5.9
Left thalamus	−12	−16	12	0.003	20	5.7
Right putamen	26	−6	8	0.005	14	5.5
Right supplemental motor area	8	12	50	0.005	15	5.4
Right caudate	14	14	8	0.002	26	5.4
Left precentral gyrus	−52	22	28	0.004	17	5.3
Left precentral gyrus	−56	4	22			5.1
Left PAG PPI effects, women > men
Right supplemental motor area	10	20	68	0.007	11	5.7

^aThe contrast “High pain > Low pain” was used and cluster peak locations (x, y, z) are given in MNI coordinates. All results are derived from a statistical threshold of P< .05, FWE corrected for multiple comparisons with clusters encompassing >10 voxels. No significant sex differences in PPI effects were observed for the right PAG.