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(a) the alpha-ketoheterocycle inhibitor (9Z)-1-(5-pyridin-2-yl-1,3,4-oxadiazol-2-yl)octadec-9-en-1-one (control), and TCM candidates (b) Guineensine and Retrofractamide A. Guineensine and Retrofractamide A differ in the number of carbons found in the hydrophobic tail region. The number of carbons for Guineensine is depicted in blue and that for Retrofractamide A is depicted in gray.
