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. 2013 Jan 30;7:6. doi: 10.3389/fncel.2013.00006

Figure 2.

Figure 2

Receptors involved in microglial phagocytosis of endogenous structures. (A), Apoptotic cells; (B), Neurites; (C), Aβ aggregates/fibrils; (D), Myelin debris. Receptors have been classified into major functional/structural groups: phosphatidylserine (PS) receptors, integrin receptors, Ig superfamily-receptors, and scavenger and related receptors. For more details on the receptors, refer to Table 1. For receptors involved in the recognition of necrotic cells and microbes, refer to the main text. Abbreviations: Aβ, β-amyloid protein; BAI-1, brain angiogenesis inhibitor 1; CR, complement receptor; DAP12, DNAX-activation protein of 12 KDa; Hsp60, heat-shock protein of 60 KDa; MARCO, macrophage receptor with collagenous structure; Mer-TK, Mer tyrosine kinase; MFG-E8, milk fat globule-epidermal growth factor; Ox-LDL, oxidized low density lipoprotein; PS, phosphatidylserine; PSR, phosphatidylserine receptor; SIRPβ1, signal regulatory protein β1; SR-A, scavenger receptor class A; SR-B1, scavenger receptor class B1; TIM, T-cell-immunoglobulin-mucin; TLR, toll-like receptor; TREM2, triggering receptor expressed on myeloid cells 2; VnR, vitronectin receptor.