Table 3.
Association analysis between the polymorphisms of Rab37 and the risk of ESCC in ESCC patients and cancer free controls.
| Patients | Controls | P value | OR [95%CI] | P value | |
|---|---|---|---|---|---|
| rs9904078 | |||||
| H-W P value | 0.6032 | 0.6583 | |||
| Genotype | N=212 | N=213 | 0.378 | ||
| G/G | 151(71.2%) | 164(77.0%) | 1a | ||
| A/G | 57(26.9%) | 45(21.1%) | 1.38[0.88-2.16] | 0.163 | |
| A/A | 4(1.9%) | 4(1.9%) | 1.09[0.27-4.42] | 0.908 | |
| A/G+A/Ab | 61(28.8%) | 49(23.0%) | 0.175 | 1.35[0.87-2.09] | 0.175 |
| A/G+G/Gc | 208(98.1%) | 209(98.1%) | 0.995 | 1.00[0.25-4.03] | 0.995 |
| Allele | 2N=414 | 2N=426 | 0.223 | ||
| G | 359(84.6%) | 373(87.6%) | 1a | ||
| A | 65(15.4%) | 53(12.4%) | 1.27[0.86-1.88] | 0.223 | |
| rs2034310 | |||||
| H-W P value | 0.5393 | 0.9954 | |||
| Genotype | N=212 | N=213 | 0.227 | ||
| C/C | 105(49.5%) | 92(43.2%) | 1a | ||
| C/T | 91(42.9%) | 96(45.1%) | 0.83[0.56-1.24] | 0.364 | |
| T/T | 16(7.5%) | 25(11.7%) | 0.56[0.28-1.11] | 0.096 | |
| C/T+T/Td | 107(50.5%) | 121(56.8%) | 0.190 | 0.77[0.53-1.14] | 0.190 |
| C/T+C/Ce | 196(92.5%) | 188(88.3%) | 0.144 | 1.63[0.84-3.15] | 0.144 |
| Allele | 2N=414 | 2N=426 | 0.099 | ||
| T | 123(29.0%) | 146(34.3%) | 1a | ||
| C | 301(71.0%) | 280(65.7%) | 1.28[0.95-1.71] | 0.099 | |
| rs5018106 | |||||
| H-W P value | 0.8465 | 0.8518 | |||
| Genotype | N=212 | N=213 | 0.849 | ||
| T/T | 167(78.8%) | 163(76.5%) | 1a | ||
| C/T | 42(19.8%) | 47(22.1%) | 0.87[0.55-1.39] | 0.567 | |
| C/C | 3(1.4%) | 3(1.4%) | 0.98[0.19-4.91] | 0.977 | |
| C/T+C/Cf | 45(21.2%) | 50(23.5%) | 0.578 | 0.88[0.56-1.39] | 0.578 |
| C/T+T/Tg | 209(98.6%) | 210(98.6%) | 0.995 | 1.00[0.20-4.99] | 0.995 |
| Allele | 2N=414 | 2N=426 | 0.614 | ||
| T | 376(88.7%) | 373(87.6%) | 1a | ||
| C | 48(11.3%) | 53(12.4%) | 0.90[0.59-1.36] | 0.614 | |
| Haplotype | 2N=414 | 2N=426 | 0.192 | ||
| A-C-C h | 0.51(0.1%) | 0.33(0.1%) | - | - | - |
| A-C-T | 50.85(12.0%) | 40.84(9.6%) | 0.255 | 1.288 [0.83-1.99] | 0.255 |
| A-T-C h | 3.42(0.8%) | 3.01(0.7%) | - | - | - |
| A-T-T | 10.22(2.4%) | 8.81(2.1%) | 0.734 | 1.171 [0.47-2.91] | 0.734 |
| G-C-C | 12.34(2.9%) | 4.96(1.2%) | 0.071 | 2.551 [0.89-7.30] | 0.071 |
| G-C-T | 237.30(56.0%) | 233.87(54.9) | 0.736 | 1.048 [0.80-1.38] | 0.736 |
| G-T-C | 31.73(7.5%) | 44.70(10.5%) | 0.127 | 0.691 [0.43-1.11] | 0.127 |
| G-T-T | 77.63(18.3%) | 89.48(21.0%) | 0.328 | 0.844 [0.60-1.19] | 0.328 |
OR: Odds Ratio. CI: Confidence Intervals. H-W: Hardy-Weinberg equilibrium. a Reference genotype/allele. b Comparing subjects with A/G+A/A genotypes vs. G/G genotype. c Comparing subjects with A/G+G/G genotypes vs. A/A genotype. d Comparing subjects with C/T+T/T genotypes vs. C/C genotype. e Comparing subjects with C/T+C/C genotypes vs. T/T genotype. f Comparing subjects with C/T+C/C genotypes vs. T/T genotype. g Comparing subjects with C/T+T/T genotypes vs. C/C genotype. h All those frequency < 1 % will be ignored in analysis.