Table 4.
The association analysis between the polymorphisms of Rab37 and the clinic TNM stage of ESCC patients.
| TNM stage | P value | OR [95%CI] | P value | ||
|---|---|---|---|---|---|
| I-IIa | IIb-IV | ||||
| rs2034310 | |||||
| Genotype | N=162 | N=50 | 0.983 | ||
| T/T | 12(7.4%) | 4(8.0%) | 1a | ||
| C/T | 70(43.2%) | 21(42.0%) | 1.11[0.32-3.81] | 0 .867 | |
| C/C | 80(49.4%) | 25(50.0%) | 1.07[0.32-3.60] | 0 .917 | |
| C/T+C/Cb | 150(92.6%) | 46(92.0%) | 0 .890 | 1.09[0.33-3.53] | 0 .890 |
| C/T+T/Tc | 82(50.6%) | 25(50.0%) | 0 .939 | 1.02[0.54-1.93] | 0 .939 |
| Allele | 2N=324 | 2N=100 | 0.998 | ||
| T | 94(29.0%) | 29(29.0%) | 1a | ||
| C | 230(71.0%) | 71(71.0%) | 1.00 [0.61-1.64] | 0.998 | |
| rs5018106 | |||||
| Genotype | N=162 | N=50 | 0.927 | ||
| T/T | 128(79.0%) | 39(78.0%) | 1a | ||
| C/T | 32(19.8%) | 10(20.0%) | 0.98 [0.44-2.16] | 0.950 | |
| C/C | 2(1.2%) | 1(2.0%) | 0.61 [0.05-6.90] | 0.686 | |
| C/T+C/Cd | 34(21.0%) | 11(22.0%) | 0.878 | 0.94[0.44-2.03] | 0.878 |
| C/T+T/Te | 160(98.8%) | 49(98.0%) | 1.000 | 1.63[0.14-18.39] | 1.000 |
| Allele | 2N=324 | 2N=100 | 0.806 | ||
| T | 288(88.9%) | 88(88.0%) | 1a | ||
| C | 36(11.1%) | 12(12.0%) | 0.92 [0.46-1.84] | 0.806 | |
| rs9904078 | |||||
| Genotype | N=162 | N=50 | 0.986 | ||
| G/G | 115(71.0%) | 36(72.0%) | 1a | ||
| A/G | 44(27.2%) | 13(26.0%) | 1.06 [0.51-2.18] | 0.875 | |
| A/A | 3(1.9%) | 1(2.0%) | 0.94 [0.09-9.31] | 0.957 | |
| A/G+A/Af | 47(29.0%) | 14(28.0%) | 0.890 | 1.05[0.52-2.13] | 0.890 |
| A/G+G/Gg | 159(98.1%) | 49(98.0%) | 1.000 | 1.08[0.11-10.64] | 1.000 |
| Allele | 2N=324 | 2N=100 | 0.917 | ||
| G | 274(84.6%) | 85(85.0%) | 1a | ||
| A | 50(15.4%) | 15(15.0%) | 1.03 [0.56-1.93] | 0.917 | |
OR: Odds Ratio. CI: Confidence Intervals. a Reference genotype/allele. b Comparing subjects with C/T+C/C genotypes vs. T/T genotype. c Comparing subjects with C/T+T/T genotypes vs. C/C genotype. d Comparing subjects with C/T+C/C genotypes vs. T/T genotype. e Comparing subjects with C/T+T/T genotypes vs. C/C genotype. f Comparing subjects with A/G+A/A genotypes vs. G/G genotype. g Comparing subjects with A/G+G/G genotypes vs. A/A genotype.