Table 2.
Genes and single nucleotide polymorphisms (SNPs) in the heme iron metabolic pathway on the Affymetrix 6.0 array that passed quality control.
| Gene | Chromosome | SNPs |
|---|---|---|
| ACO1 | 24 | rs1028932, rs10435797, rs10813816, rs13293491, rs10813818, rs2026739, rs7032871, rs10738885, rs16918276, rs3780473, rs3780474, rs4495514, rs13302577, rs7866419, rs7022554, rs4879583, rs10970961, rs7033149, rs10970972, rs10970974, rs7019520, rs13292540, rs13293491, rs3780474 |
| ALAD | 7 | rs8177800, rs8177804, rs818684, rs2761016, rs8177812, rs1805313, rs1805316 |
| ALAS1 | 6 | rs352166, rs352167, rs352169, rs11712164, rs352170, rs9813468 |
| BLVRA | 8 | rs10234057, rs849161, rs699510, rs849162, rs849165, rs10233867, rs10268054, rs1317916 |
| BLVRB | 1 | rs2613843 |
| CP | 17 | rs17787768, rs3816893, rs772908, rs16861598, rs16861634, rs16861590, rs4974389, rs701755, rs7652826, rs13072552, rs16861577, rs13075921, rs9853335, rs1879169, rs773050, rs16861579, rs11924961 |
| CPOX | 2 | rs3804622, rs1675534 |
| FECH | 20 | rs1788002, rs1790619, rs492274, rs317806, rs8094527, rs533952, rs12969847, rs1041951, rs7243988, rs317807, rs12454808, rs2269221, rs2269222, rs8099511, rs1736439, rs8092783, rs2272783, rs8095390, rs12968109, rs7242288 |
| FTH1 | 2 | rs5904861, rs195154 |
| HAMP | 1 | rs8101606 |
| HFE | 3 | rs1800562, rs2071303, rs2858996 |
| HFE2 | 2 | rs10218795, rs7540883 |
| HMBS | 7 | rs1799993, rs1784304, rs1006195, rs494048, rs1144041, rs17075, rs549893 |
| HMOX1 | 7 | rs9306300, rs8140669, rs2071749, rs8140370, rs2285112, rs5995097, rs2269533 |
| HMOX2 | 16 | rs4786500, rs2160567, rs1362626, rs9302781, rs11076834, rs3789038, rs4786501, rs2270366, rs10500325, rs8063084, rs4785969, rs9929475, rs7192051, rs9936357, rs8048958, rs8055559 |
| IL6 | 7 | rs2069837, rs2066992, rs2069835, rs1548216, rs2069842, rs2069840, rs1474347 |
| IL6R | 16 | rs11265618, rs4845626, rs4537545, rs10752641, rs4240872, rs11265610, rs6694817, rs6427658, rs4845618, rs10159236, rs6689393, rs12060250, rs4129267, rs8192282, rs4537545, rs10752641 |
| IREB2 | 18 | rs13180, rs2568491, rs9920411, rs924840, rs17483929, rs16969899, rs2656071, rs16969858, rs17483721, rs905742, rs8043227, rs10519198, rs7181486, rs2568483, rs2656073, rs8041628, rs11636431, rs2568492 |
| SLC11A2 | 6 | rs17125212, rs2269683, rs224572, rs224573, rs224568, rs224589 |
| SLC25A37 | 33 | rs7826247, rs2872716, rs17089392, rs2942194, rs17089394, rs7833754, rs7834536, rs17089335, rs11778179, rs2928672, rs752778, rs7846025, rs3736032, rs7834883, rs7830129, rs2928665, rs7816824, rs10503725, rs17698981, rs2942204, rs2978471, rs2978475, rs17089332, rs11781222, rs7015818, rs12548753, rs7829094, rs13266950, rs17089358, rs2004644, rs4871881, rs4871880, rs7834536 |
| SLC40A1 | 10 | rs4667287, rs2304704, rs1439816, rs930373, rs1123110, rs3792079, rs11568350, rs13431938, rs1123109, rs13404407 |
| SMAD4 | 5 | rs3764465, rs10502913, rs16952790, rs12457540, rs948588 |
| STAT3 | 16 | rs3809758, rs2306580, rs4796646, rs17880900, rs8069645, rs3785898, rs7215104, rs744166, rs4796644, rs8078731, rs8074524, rs6503698, rs1026916, rs7211777, rs3816769, rs9912773 |
| STEAP3 | 30 | rs838075, rs708675, rs3769659, rs838074, rs12711924, rs41527945, rs7596511, rs838083, rs708672, rs838072, rs708670, rs865688, rs838095, rs12465926, rs11888609, rs838103, rs12990907, rs10182241, rs838090, rs1867856, rs10188946, rs838092, rs4592854, rs12104548, rs838079, rs6542517, rs838102, rs1867749, rs13401854, rs6720040 |
| TF | 37 | rs4854759, rs8177201, rs1358022, rs8177203, rs8177306, rs1049296, rs2715627, rs1799852, rs7638018, rs4241357, rs7633232, rs6778321, rs1800277, rs8177241, rs8177232, rs2715631, rs8177277, rs8177235, rs8177220, rs8177238, rs8177233, rs2715632, rs8177272, rs12493168, rs2718796, rs1115219, rs8177253, rs8177318, rs8177224, rs7628133, rs8177248, rs1525892, rs8177262, rs7645538, rs8177191, rs8177215, rs3811657 |
| TFR2 | 1 | rs4521695 |
| TFRC | 6 | rs3933, rs3804141, rs3804142, rs4927866, rs480760, rs12330245 |
| UROD | 1 | rs13948 |
| UROS | 12 | rs10510149, rs1571278, rs2281956, rs10794025, rs3814624, rs11244653, rs10901450, rs2027515, rs3740179, rs10751533, rs2149019, rs12251135 |