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. Author manuscript; available in PMC: 2013 Jan 30.
Published in final edited form as: NMR Biomed. 2011 Jan 17;24(6):569–581. doi: 10.1002/nbm.1632

Figure 2.

Figure 2

HIF-1 as a regulator of cellular response to hypoxia

A) Scheme showing the hypoxic regulation of hif-1 by hypoxia, and the panel of responses induced by stabilization of hif-1alpha in hypoxic cells.

B) BOLD contrast MRI showing response to hyperoxia in Hif-1 alpha deficient ES-teratomas, from (55).

C) Hif-1 beta deficient tumors: T2* maps from a WT (a) and a c4 hif-1 beta mutant (b) tumor. Signal intensity, related to hemoglobin oxygenation, demonstrates the heterogeneity within each individual tumor rather than consistent differences between the WT and c4 tumors. Reproduced from (56).

D) VHL tumors. BOLD contrast MRI of Hippel-Lindau VHL tumors showing vascular response to hypercapnia and hyperoxia. Halo, treatment with halofuginone as antiangiogenic therapy, reproduced from (57).