Table 1.

Glucose-stimulated insulin secretion from pancreatic islets of B6 and KKA^y mice treated with or without vildagliptin

	3 mM (ng/ml/islet)	16.7 mM (ng/ml/islet)	Fold-increase (high GLC/low GLC)
B6 control	0.47 ± 0.07	2.96 ± 0.27	6.63
B6 vildagliptin treated	0.48 ± 0.06	4.34 ± 0.32*	9.43*
KKAy control	0.34 ± 0.04	1.06 ± 0.07*	3.43*
KKAy vildagliptin treated	0.30 ± 0.07	1.81 ± 0.30†	6.42†

Data are presented as the mean ± s.e. (ng/ml/islet, five independent experiments per group).

^*p < 0.05 vs. control B6 mice.

^†p < 0.05 vs. control KK-A^y mice.