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The effect of 1S,3R-ACPD on the firing pattern of CA1 pyramidal neurons. (A) Representative traces showing the firing patterns evoked by a depolarizing current step (500 ms) in a CA1 pyramidal neuron recorded from adult WT mice (Vh= −70 mV). Note the spike adaptation under control conditions and the burst in the presence of 30 μM 1S,3R-ACPD, a mGluR agonist. (B) Spontaneous firing in the same CA1 pyramidal neuron under the control conditions and in the presence of 30 μM 1S,3R-ACPD.
