TABLE 5.

Effect of PSNCBAM-1 on [³H]CP55940 (0.5 nM) dissociation from hCB₁ cell membranes

Data shown are mean ±S.E.M. of 3 independent experiments. *P < 0.05 **P < 0.01 one-way ANOVA followed by Dunnett’s multiple comparison.

	Slow Phase	Koff (Slow)	Koff (Fast)
	%	min–1 ×10−2	min–1 × 10−2
[3H]CP55 +Vehicle	59.7 ± 1.9	1.1 ± 0.2	32 ± 20
[3H]CP55 + 30 nM PSN	64.4 ± 3.9	1.2 ± 0.1	63 ± 22
[3H]CP55 + 100 nM PSN	79.0 ± 4.0**	0.9 ± 0.1	34 ± 9
[3H]CP55 + 2 μM PSN	100 ± 0**	0.4 ± 0.04*	—