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. 2013 Feb;344(2):378–387. doi: 10.1124/jpet.112.200832

Fig. 2.

Fig. 2.

NHL cell lines are more reliant on SYK for survival than primary B-cells. (A) NHL cell lines treated with vehicle control, 1 µM or 3 µM P505-15. Histograms (representative of 2–3 experiments) depict induction of apoptosis via caspase 3 cleavage on the x-axis. The three sensitive cell lines are shown on the top row, and the two resistant lines on the bottom row. (B) the side scatter (SSC) by CD19 scatter plots depict primary B-cell and SU-DHL6 gating strategies for human whole blood leukocytes (left plot) and human whole blood mixed with SU-DHL6 (right plot). Second row histograms depict primary B-cell or SU-DHL6 apoptosis following treatment with 1 µM P505-15 for 24 hours. The dotted line represents vehicle control while the shaded gray histogram represents P505-15 treatment.