Fig. 3.

SYK inhibition prevents NHL tumor formation in xenograft mice. Mice were dosed twice daily with 10, 15, or 20 mg/kg P505-15 or vehicle control beginning the day of tumor cell inoculation. (A) individual tumor weights (n = 13–15) were determined at 4 weeks postinoculation for each treatment condition. Statistical differences relative to vehicle control are depicted as P values within the graph. (B) Values shown depict blood cell counts (mean + S.D., n = 13-15) of mice treated with each concentration of P505-15 or vehicle control.