TABLE 1.

Steady-state plasma and tumor pharmacokinetics following oral dosing of P505-15 in mice

Plasma and tumor composite PK analysis from steady-state Cmin (collected 16 hours following the penultimate dose) and 1.5, 4, and 8 hours post-last dose on day 27.

Dosing Regimen	Tmax	Cmin	Cmax	AUC (0–8 hours)
	hours	nM	nM	ng*h/ml
Determined from Plasma
10 mg/kg BID	1.5	45	466	738
15 mg/kg BID	1.5	69	893	1671
20 mg/kg BID	4.0	102	1484	3191
Determined from Tumor
10 mg/kg BID	8.0	63	143	353
15 mg/kg BID	4.0	176	424	475
20 mg/kg BID	4.0	325	656	1453