Fig. 13.

Time course for inhibition of rat plasma cholinesterase functional activity by nerve agent model compound Sp-GD tertiary amine (Barakat et al., 2009) or GD after administration to rats. (A) Comparison of inhibition of rat plasma cholinesterase by nerve agent model compound Sp-GD (□) (250 μg/kg, i.p.) and GD (○) (88 μg/kg, i.p) (modified from Geller et al., 1987). (B) Comparison of time course (0–10 days) for inhibition of rat plasma cholinesterase activity by nerve agent model compound Sp-GD tertiary amine (□) (250 μg/kg, i.p.) (Barakat et al., 2009) and GD (◯) (25.5 μg/kg, i.p.) (modified from Jovic, 1974).