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. 2013 Feb;344(2):511–521. doi: 10.1124/jpet.112.199745

Fig. 3.

Fig. 3.

Striatal DAT binding density after single or repeated exposure to a neurotoxic regimen of METH (mean ± S.E.M.; n = 5–12). Treatment group designations indicate PND60 treatment:PND90 treatment, resulting in the four treatment groups: Saline:Saline (SS), METH:Saline (MS), Saline:METH (SM), and METH:METH (MM). (A) Animals sacrificed 1 hour after the last injection on PND90. ***Main effect of PND60 treatment, P < 0.001. (B) Animals sacrificed 48 hours after the last injection on PND90. **SS group significantly different from all other groups, P < 0.005; ††MS group significantly different from all other groups; P < 0.005; ‡‡‡SM group significantly different from all other groups, P < 0.005. (C) Representative images of DAT autoradiography in animals sacrificed 48 hours after the last injection. Scale bar = 2 mm, applies to all images.