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. 2013 Feb;344(2):511–521. doi: 10.1124/jpet.112.199745

Fig. 7.

Fig. 7.

Quantitative analysis of the effects of single or repeated METH exposure on nNOS mRNA expression in the striata of animals sacrificed 1 hour or 48 hours after the last injection on PND90. Treatment group designations indicate PND60 treatment:PND90 treatment, resulting in the four treatment groups: Saline:Saline (SS), METH:Saline (MS), Saline:METH (SM), and METH:METH (MM). Values are expressed as the mean number of cells expressing nNOS per square millimeter of the imaged striatal sections (A; mean ± S.E.M.; n = 4–12) and the mean density (i.e., average [avg.] gray value) of the nNOS signal per labeled cell (B) in the striatal sections analyzed. No significant differences among treatment groups were observed. (C) Representative images of nNOS mRNA in situ hybridization histochemical staining in rats sacrificed 48 hours after the last injection on PND90. Scale bar = 2 mm, applies to all images.