TABLE 3.
Ratio of MDMA to metabolites in rats and mice at two different temperatures
Calculations are based on peak plasma concentrations (Cmax) and areas under the curve (AUC) obtained in rats and mice treated with a single oral dose of MDMA at 25°C and 4°C ambient temperatures. The significance of differences between means at both temperatures was determined using two-tailed paired Student’s t tests, and significance was assumed when P < 0.05. Values represent the mean ± S.E.M. (n = 9). No significant difference was found when MDMA/metabolite ratios were compared between both temperatures in rats.
| Rat | Mouse | |||||||
|---|---|---|---|---|---|---|---|---|
| Cmax Ratio | AUC Ratio | Cmax Ratio | AUC Ratio | |||||
| 25°C | 4°C | 25°C | 4°C | 25°C | 4°C | 25°C | 4°C | |
| MDMA/MDA | 2.2 ± 0.5 | 2.8 ± 0.4 | 1.2 ± 0.1 | 1.6 ± 0.2 | 5.9 ± 0.6 | 10.4 ± 0.8* | 4.6 ± 0.3 | 7.2 ± 0.6* |
| MDMA/HMMA | 4.8 ± 1.0 | 5.7 ± 0.9 | 2.2 ± 0.2 | 2.6 ± 0.3 | 7.1 ± 1.1 | 11.3 ± 0.8* | 7.4 ± 0.7 | 11.2 ± 0.9* |
| MDMA/HHMA | 6.0 ± 0.8 | 7.7 ± 1.2 | 3.1 ± 0.4 | 4.0 ± 0.7 | 8.6 ± 1.5 | 14.3 ± 1.2* | 8.2 ± 0.8 | 11.9 ± 0.7* |
*
P < 0.05 vs. ratios at 25°C in mice.