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(A) Plasma and (B) brain concentrations of opioids (mean ± S.D.) after 1-minute infusion of heroin 0.26 mg/kg i.v (n = 4 per time point). Heroin concentrations were above the limit of quantitation (5 ng/ml) in plasma and brain at 1-minute post-infusion and estimated at 4 minutes. ***P < 0.001 compared to heroin concentrations; †P < 0.05 and †††P < 0.001 compared to morphine concentrations.
