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. 2013 Feb;344(2):397–406. doi: 10.1124/jpet.112.201194

Fig. 7.

Fig. 7.

Plasma and brain concentrations of 6-MAM and morphine (mean ± S.D.) 4 minutes after a 1-minute infusion of 0.23 mg/kg 6-MAM in M-KLH and KLH rats (n = 5 per group). Rats were tested after the fifth vaccination i.p. with 25 μg M-KLH + Freund’s, s.c. with M-KLH + alum, and i.p. with 25 μg KLH + Freund’s (n = 5 per group). Brain concentrations of morphine were below detection in all groups. **P < 0.01 and ***P < 0.001 compared to KLH controls; ††P < 0.01 and †††P < 0.001 compared to M-KLH + alum s.c. Numbers in parentheses are the percent decrease compared to controls.