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. 2013 Feb;344(2):397–406. doi: 10.1124/jpet.112.201194

Fig. 9.

Fig. 9.

(A) Vaccine effect on drug-induced anti-nociception in M-KLH (n = 14) and KLH (n = 8) rats after s.c. administration of heroin (1.0 mg/kg), methadone (2.25 mg/kg), oxycodone (2.25 mg/kg), and nicotine (0.35 mg/kg) and in M-KLH (n = 10) and KLH (n = 10) rats after s.c. administration of fentanyl (0.05 mg/kg). Data are the mean percent maximum possible effect [% maximum possible effect (MPE)] ± S.E.M. *P < 0.05, **P < 0.01, and ***P < 0.001 compared to KLH controls. Numbers in parentheses are the percent decrease of %MPE in M-KLH compared to KLH controls. (B) Vaccine effect on heroin-induced locomotor activity in M-KLH (n = 14) and KLH (n = 8) rats. Total horizontal distance traveled (mean ± S.E.M.) was measured for 90 minutes after s.c. administration of 0.25 mg/kg heroin. ***P < 0.001 heroin-induced locomotor activity compared to KLH controls. (C) Relationship of log morphine-specific IgG concentrations and locomotor activity in M-KLH (n = 14) and KLH (n = 8) rats on day 16.