TABLE 2.

Molar ratios of opioid-specific binding sites and opioid dose

Opioid Administered	Opioid Dose	Vaccine Adjuvant and Route	Total Opioid-specific IgG Binding Sites	Molar Ratio of Drug Dose: IgG Binding Sites
	μmol/kg		μmol/kg
Heroin i.v.	0.703	Freund’s, i.p.	0.42	1.7
6-MAM i.v.	0.703	Freund’s, i.p.	1.09	0.6
		Alum, s.c.	0.22	3.2
Heroin s.c.	2.70a	Freund’s, i.p.	0.95	2.8
	0.68b	Freund’s, i.p.	0.42	1.6*

^aHeroin-induced anti-nociception study.

^bHeroin-induced locomotor activity study.

^*Molar ratios reflect single doses though repeated doses were used to test behavioral responses in these protocols.