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. 2004 Mar;72(3):1637–1644. doi: 10.1128/IAI.72.3.1637-1644.2004

FIG. 2.

FIG. 2.

Effect of endogenous leukotriene synthesis inhibition on mouse survival rate and on fungal recovery. (A) Survival of mice after i.t. PBS injection and daily p.o. administration of water or MK 886, after i.t. infection with H. capsulatum yeast cells and daily p.o. administration of water or MK 886, after i.t. inoculation with dead Hc yeast cells and daily p.o. administration of water or MK 886 as indicated. Mice were monitored for 30 days (n = 6 to 8). (B) Fungal burden in lungs. (C) Fungal burden in the spleen. Tissue samples were harvested at 7 and 14 days of H. capsulatum infection with daily administration of water or MK 886. The data are expressed as mean ± the SEM from three experiments (n = 12). ✽, Hc+H2O versus Hc+MK; P < 0.05. n.f., No yeast cells found; MK, MK 886; Hc, H. capsulatum.