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Efflux of 17-OHPC in the presence (CyA) and absence (No CyA) of cyclosporine A in primary human adult and fetal hepatocytes. The results are expressed as 17-OHPC efflux relative to total 17-OHPC uptake (amount in media + cell lysate). Each bar represents the mean of triplicate treatments (±S.D.). Inhibition (statistically significant for *P < 0.05) of 17-OHPC efflux was observed in the presence of CyA.
