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Cellularly derived metabolic transformation products correspond to those derived enzymatically. HPLC profiles of C-1305 (A) or C-1311 (B) after transformation by UGT1A10 in KB-3 cells (solid line) or in vitro with recombinant enzyme (dotted line) superimposed to confirm identity of glucuronide. Panels to the right show electrospray ionization-mass spectrometry analysis of the corresponding glucuronide products.
