Figure 4. Pathological and imaging evidence of white matter disease.

Normal white matter seen on gross inspection (A) and microscopically (B). Severe white matter pallor (C) indicating rarefaction and demyelination microscopically (D). These findings are consistent with white matter hyperintensities (E) which characteristically surround the ventricles throughout subcortical white matter (arrow). These WMHs also disrupt fiber tracts, seen in (F) using diffusion tensor imaging tractography.