Table II. Interactions between NS5A and cellular proteins.
| Protein | NS5A interaction residues | Functional role | Ref. |
|---|---|---|---|
| 2-5A synthase | 1-148 | Inhibition of IFN signaling | 87 |
| Actin | Movement of replication complexes | 27 | |
| Akt | 38 | ||
| Amphiphysin II | 350-356 | Modulation of NS5A phosphorylation | 88, 89 |
| Annexin A2 | domain 3 | Assembly of infectious virus | 90 |
| Apo-AI | Promotion of HCV-induced steatosis | 17 | |
| Apo-E | 205-280 | Assembly of infectious virus | 91 |
| BAX | 262-277 | Inhibition of apoptosis | 92 |
| β-Catenin | 1-144 | Inhibition of apoptosis | 93 |
| Myc box-dependent- interacting protein 1 |
348-356 | Inhibition of apoptosis | 94 |
| CDK1 | Modulation of cell cycle | 95 | |
| CKI-α | Phosphorylation of NS5A | 39, 49 | |
| CK II | carboxy-terminus | Phosphorylation of NS5A | 40 |
| Cyclophilin A | 304-320 | 96 | |
| Cyclophilin B | 310-315 | 96 | |
| FKBP38 | 148-236 | Inhibition of apoptosis | 97, 98 |
| FKBP8 | 121 | Stimulation of HCV RNA replication | 99 |
| Fyn | 350-356 | HCV replication and pathogenesis | 100 |
| GRB2 | 350-356 | Disruption of signal transduction pathway | 101 |
| hB-ind1 | Stimulation of HCV RNA replication | 102 | |
| HCK | 350-356 | HCV replication and pathogenesis | 100 |
| HSP 27 | 1-181 | 103 | |
| Heat shock 70 kDa protein 2 |
221-302 | Stimulation of HCV RNA replication | 104 |
| hTAFII32 | 175-179 | 105 | |
| hVAP-33 | Membrane association of replication complexes | 106 | |
| hVAP-A | 213, 215 | Stimulation of HCV RNA replication | 107 |
| hVAP-B | 66-70, 341-344 | Stimulation of HCV RNA replication | 108 |
| ISG15 | 379 | ISGylation of NS5A | 109 |
| Karyopherin β-3 | 1-200 | 110 | |
| La | 1-83 | 111 | |
| Lck | 350-356 | HCV replication and pathogenesis | 100 |
| Lyn | 343-356 | HCV replication and pathogenesis | 100 |
| MEK 1 | 38 | ||
| MEK 6 | 38 | ||
| MyD88 | 240-280 | Modulation of TLR signaling pathway | 112 |
| OSBP-related protein | 1-147 | HCV particle maturation and release | 113 |
| p53 | 1-150 | Modulation of cell cycle | 114 |
| p70 S6K | 38 | ||
| PI3K | 270-300 | Inhibition of apoptosis | 115 |
| PIP4KIII-α | 116 | ||
| PKA | Phosphorylation of NS5A | 41 | |
| PKR | 237-276 | Inhibition of IFN signaling | 117 |
| PLK1 | Phosphorylation of NS5A | 42 | |
| PTX1 | 133-220 | Modulation of IFN activity | 118 |
| Raf-1 | Stimulation of HCV RNA replication | 119 | |
| SRCAP | Modulation of cell cycle | 120 | |
| STAT1 | Inhibition of IFN signaling | 121 | |
| SYK | 1-175, 237-302 | Inhibition of tumor suppression | 122 |
| TBC1 domain family member 20 | 1-100 | Stimulation of HCV RNA replication | 123 |
| TBP | 124 | ||
| TRADD | 125 | ||
| TRAF2 | 148-301 | HCV pathogenesis | 126 |
| Tubulin | Movement of replication complexes | 27 | |
| TβR-I | 148-238 | Modulation of TGF-β signaling | 127 |