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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: Chem Biol. 2013 Jan 24;20(1):102–110. doi: 10.1016/j.chembiol.2012.10.021

Figure 1. Screening of molecules with anti-biofilm activity.

Figure 1

384 well microplates filled with MSgg medium were inoculated with B. subitlis 3610 cells and aliquots of a collection of small molecules at a final concentration of 12.5 μg/ml were added. After 24 h of incubation, plates were assessed for presence or absence of pellicles. (A) A close view of one of the plates showing the inhibition of pellicle provoked by two different molecules, (B) Structure of AA-861, a benzoquinone derivative, and (C) parthenolide, a sesquiterpene lactone. (D) A growth curve of B. subtilis 3610 in MSgg liquid medium showed no variation in bacterial growth in the absence (○) or presence of 50 μM of AA-861 (■), or parthenolide (×).