Figure 2. TasA is the main target of the anti-biofilm molecules.
Biofilm assays were performed to determine the main target of AA-861 and parthenolide. MSgg medium was inoculated with cells of wild-type, eps or tasA single mutants or double tasA, eps mutant. The molecules were added at 50 μM. DMSO was used as a negative control. Images of pellicles were taken after 24 hr of incubation at 30°C with no agitation (see also Figure S1 and Figure S2).