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. Author manuscript; available in PMC: 2014 Jan 24.
Published in final edited form as: Chem Biol. 2013 Jan 24;20(1):102–110. doi: 10.1016/j.chembiol.2012.10.021

Figure 4. The molecules inhibit the polymerization of TasA in vitro.

Figure 4

(A) Thioflavin T and fluorescence were used to study the kinetics of polymerization of TasA. Purified TasA was treated with formic acid, dried under vacuum and mixed with physiological buffer (○) or DMSO (▲), plus 50 μM of AA-861 (●) or parthenolide (□). Transmission electron micrographs of samples taken after 24 hr of incubation of (B) TasA in buffer, (C) TasA treated with DMSO, (D) TasA treated with AA-861 and (E) TasA treated with parthenolide. Scale bars, 100 nm.