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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Clin Lipidol. 2012 Apr 22;7(1):65–81. doi: 10.1016/j.jacl.2012.04.079

Figure 2.

Figure 2

The genes express in six main locations: in the brain, adipocyte, kidney, liver, arterial endothelium and β-cell. Perturbations in metabolic pathways programmed by the respective genes result in alterations in plasma metabolites (lipids carried in lipoproteins, glucose and fatty acids) and insulin, resulting in progression of metabolic syndrome traits leading to disease expression. Effects of insulin resistance are shown by the red lines.