Table 4.
Influence of organic solvent and amount of polymer on the nanoparticle properties
| Batch | Composition | Nanoparticle properties** | ||||
|---|---|---|---|---|---|---|
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|
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| Solvent | PCL amount (mg) | Mean diameter (nm) | PI | Entrapment efficiency (%) | Loaded alkaloid mass (mg) | |
| NP1 | MC | 50 | 386.0 ± 50.1a | 0.256 ± 0.039a | 38.2 ± 0.3* | 0.121 ± 0.025a |
| NP2 | EA | 50 | 223.5 ± 1.7b | 0.051 ± 0.018b | 33.0 ± 2.1a | 0.151 ± 0.010b |
| NP3 | EA | 100 | 260.0 ± 15.1* | 0.135 ± 0.013b | 44.6 ± 3.3b | 0.217 ± 0.003c |
Notes:
**
Mean ± standard deviation; analysis of variance Tukey’s test (α = 0.05): means with different letters indicate significant differences and the symbol * indicates that the mean is not significantly different from the other means in this analysis.
Abbreviations: EA, ethyl acetate; MC, methylene chloride; PCL, poly ɛ-caprolactone; PI, polydispersity index.