Table 5.

Influence of initial alkaloid content in the organic phase on nanoparticle properties

Batch	Composition		Nanoparticle properties*
	Organic phase	Initial alkaloid mass (mg)	Entrapment efficiency (%)	Loaded alkaloid mass (mg)	Mean diameter (nm)	PI
NP4	EA	0.4	88.5 ± 0.4a	0.351 ± 0.001a	255.3 ± 3.4a	0.071 ± 0.023a
NP8	EA:AC	1.2	83.8 ± 3.8a	0.993 ± 0.044b	408.3 ± 13.9b	0.200 ± 0.017b

Notes:

^*Mean ± standard deviation; Student’s t-test (α = 0.05): means with different letters indicate significant differences.

Abbreviations: AC, acetone; EA, ethyl acetate; PI, polydispersity index.