Table 5. Genotype Frequency of SNPs in control and PAC subjects.
| SNP | Genotype distribution N (%) |
General |
Pc 1/Pc 2 | Dominant p/OR (95% CI) | Recessive p/OR (95%CI) | ||
|---|---|---|---|---|---|---|---|
| Control | PAC | P value | |||||
| MMP9
rs17576 |
GG |
164(53.6) |
133(57.6) |
0.656 |
0.77/0.78 |
0.36/0.85
(0.60–1.20) |
0.74/0.91
(0.50–1.65) |
| GA |
113(36.9) |
78(33.8) |
|||||
| AA |
29(9.5) |
20(8.6) |
|||||
| MMP9
rs3918249 |
CC |
160(52.3) |
133(57.6) |
0.465 |
0.55/0.56 |
0.22/0.81
(0.57–1.14) |
0.53/0.82
(0.45–1.50) |
| CT |
116(37.9) |
79(34.2) |
|||||
| TT |
30(9.8) |
19(8.2) |
|||||
| MTHFR rs1801133 |
GG |
93(30.4) |
81(35.1) |
0.514 |
0.81/0.81 |
0.25/0.81
(0.56–1.16) |
0.80/0.95
(0.61–1.46) |
| GA |
152(49.7) |
106(45.9) |
|||||
| AA |
61(19.9) |
44(19.0) |
|||||
| MFRP rs3814762 |
CC |
196(64.1) |
166(71.9) |
0.027 |
0.01/0.02 |
0.06/0.70
(0.48–1.01) |
0.02/0.26
(0.07–0.89) |
| CT |
95(31.0) |
62(26.8) |
|||||
| TT |
15(4.9) |
3(1.3) |
|||||
| HSP70 rs1043618 | GG |
123(40.2) |
95(41.0) |
0.048 | 0.03/0.03 | 0.86/0.97 (0.68–1.37) | 0.02/1.79 (1.08–2.97) |
| GC |
152(49.7) |
98(42.2) |
|||||
| CC | 31(10.1) | 39(16.8) | |||||
All p values>0.05 after Bonferroni correction Pc 1: p value corrected for age and gender Pc 2: p value corrected for hypertension, diabetes and cardiovascular disease